Marked men hunters appear to be former NCR troopers, equipped with powerful ranged weapons. They may carry guns like trail carbines, assault carbines or sniper rifles at lower levels (level 1 to level 30), and anti-materiel rifles, brush guns or marksman carbines at higher levels (level 30 or above). For energy weapons, they may be seen carrying arc welders, tri-beam laser rifles or multiplas rifles.

Marked men are a unique subtype of ghoul with a fiery red tone due to their brutal environment; ghoulification made their flesh weak and fragile, but it was the storms that peeled their skin off, leaving behind only muscle. According to Ulysses, the radiation of the Divide may be the only thing keeping them alive. They congregate in squads and small camps of around four marked men and wear ramshackle faction armor.

Marked men level with the player character, have a high amount of health for humanoid opponents, and are moderately protected by the tattered armor they wear (albeit far less than properly maintained regular versions of their armor). They are overall on par with the White Legs tribals of Zion Canyon and the lobotomites of the Big MT in terms of health and armor.

Gaius Magnus is a centurion who wears the unique armor of the 87th Tribe. He is in Dry Wells with some of his legionaries, who become marked men after the Courier sends an atomic strike to the area.

He has very high health, and like other ghouls and marked men, he also constantly regenerates health from the high radiation in the area.